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The paper: `Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport` https://www.nature.com/articles/s41392-025-02426-1

"Cognitive assessments revealed that treated AD mice exhibited significant improvements in spatial learning and memory, with performance levels comparable to those of wild-type mice. These cognitive benefits persisted for up to 6 months post-treatment."

I'm curious if Derek Lowe will comment on this on his blog. I'll await his opinion on how much we ought to celebrate here. He's not a big fan of the amyloid hypothesis and has worked many years in this exact field, so I reckon he will point out why skepsis is warranted.



Yup. I hope he says something about what "nanotherapy" means.


My biggest criticism of the article is emphasizing "nanotechnology" when it is really just an extra large synthetic molecule.

I mean, it is nanotech! But just not the type most readers would imagine. They could have elaborated on an justified this better by explaining novel synthesis method or something.




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